| 1990:    The Brain, Vol. LVOrganizer: James Watson  Symposium Participants    v  Foreword    xv 		 Molecular Mechanisms for Signaling 		 Molecular Insights into Excitation-Contraction Coupling S. Numa, T. Tanabe, H. Takeshima, A. Mikami, T. Niidome, S. Nishimura, B.A. Adams, and K.G. Beam    1 	 Molecular Studies of Voltage-gated Potassium Channels E. Isacoff, D. Papazian, L. Timpe, Y.-N. Jan, and L.-Y. Jan    9  Differences in Gating among Amino-terminal Variants of Shaker Potassium Channels R.W. Aldrich, T. Hoshi, and W.N. Zagotta    19 	 The GABAA Receptor Family: Molecular and Functional Diversity P.H. Seeburg, W.                                                                                                            Wisden, T.A. Verdoorn, D.B. Pritchett, P. Werner, A. Herb, H. Lüddens, R.                                                                                                                                  Sprengel, and B. Sakmann    29 	 Glutamate Receptor GluR-K1: Structure, Function, and Expression in the Brain M.                                                                                                                        Hollmann, S.W. Rogers, A. O'Shea-Greenfield, E.S. Deneris, T.E. Hughes, G.P.                                                                                                                        Gasic, and S. Heinemann    41  Quantal Analysis of Excitatory Synaptic Mechanisms in the Mammalian Central Ner-                                                                                                                   vous System J.J.B. Jack, D.M. Kullmann, A.U. Larkman, G. Major, and K.J.                                                                                                                                     Stratford    57  Synaptic Transmission in Hippocampal Neurons: Numerical Reconstruction of Quantal IPSCs C. Busch and B. Sakmann    69 		  Excitatory Synaptic Integration in Hippocampal Pyramids and Dentate Granule Cells P. Andersen, M. Raastad, and J.F. Storm    81   Physiological Properties of Excitatory Synaptic Transmission in the Central Nervous System S. Hestrin, D.J. Perkel, P. Sah, T. Manabe, P. Renner, and R.A. Nicoll    87   Short-term Electrophysiological Actions of Insulin on Aplysia Neurons: Identification                                                                                                                             of a Possible Novel Modulatory Second-messenger Mechanism J.H. Schwartz E.                                                                                                                                       Shapiro, S.D. Brown, and A.R. Saltiel    95   Structure and Regulation of Type II Calcium/Calmodulin-dependent Protein Kinase in                                                                                                                         Central Nervous System Neurons M.B. Kennedy, M.K. Bennett, R.F. Bulleit, N.E.                                                                                                                                       Erondu, V.R. Jennings, S.G. Miller, S.S. Molloy, B.L. Patton, and L.J. Schenker    101 	 Molecular Analysis of Proteins Associated with the Synaptic Vesicle Membrane J.K.                                                                                                                                       Ngsee, W.S. Trimble, L.A. Elferink, B. Wendland, K. Miller, N. Calakos, and R H.                                                                                                                               Scheller     111  Presynaptic Mechanisms in Hippocampal Long-term Potentiation T.V.P. Bliss, M.L. Errington, M.A. Lynch, and J.H. Williams    119    Computational Implications of NMDA Receptor Channels J.M. Bekkers and C.F. Stevens    131 	  Modified Hebbian Rule for Synaptic Enhancement in the Hippocampus and the Visual Cortex T. Bonhoeffer, A. Kossel, J. Bolz, and A. Aertsen    137   Long-term Potentiation: Presynaptic Enhancement following Postsynaptic Activation of Ca + +-dependent Protein Kinases R..W. Tsien and R. Malinow     47 	Toward a Representational Hypothesis of the Role of Hippocampal Synaptic Plasticity in Spatial and Other Forms of Learning R.G.M. Morris    161 Neuronal and Network Determinants of Simple and Higher-order Features of Associa-                                                                                                                                           tive Learning: Experimental and Modeling Approaches J.H. Byrne, D.A. Baxter,                                                                                                                                                       D.V. Buonomano, and J.L. Raymond    175 	Long-term Facilitation in Aplysia: Persistent Phosphorylation and Structural                                                                                                                                            Changes S. Schacher, D. Glanzman, A. Barzilai, P. Dash, S.G.N. Grant, F.                                                                                                                               Keller, M. Mayford, and E.R. Kandel    187 	Genetic Dissection of Memory Formation in Drosophila melanogaster T. Tully, S. Boynton, C. Brandes, J.M. Dura, R. Mihalek, T. Preat, and A. Villella     203 	 Synaptic Regulation of Immediate-Early Genes in Brain P.F. Worley, A.J. Cole, TH. Murphy, B.A. Christy, Y. Nakabeppu, and J.M. Baraban    213    Inducible Proto-oncogene Transcription Factors: Third Messengers in the Brain? T.                                                                                                                                Curran, C. Abate, D.R. Cohen, P.F. Macgregor, F.J. Rauscher Ill, J.L. Sonnen-                                                                                                                            berg, J.A. Connor, and J.I. Morgan    225  	  Neural Development   An Analysis of the Cell-Cell Interactions That Control the Proliferation and Differen-                                                                                                                                                        tiation of a Bipotential Glial Progenitor Cell in Culture M.C. Raft I.K. Hart, W.D. Richardson, and L.E. Lillien    235   Role of Helix-Loop-Helix Proteins in Drosophila Neurogenesis H. Vaessin, M. Caudy, E. Bier, L.-Y. Jan, and Y.-N. Jan    239 Generation of Neuronal Diversity: Analogies and Homologies with Hematopoiesis H. Nawa, T. Yamamori, T. Le, and P.H. Patterson    247 Contributions of Cell-extrinsic and Cell-intrinsic Factors to the Differentiation of a                                                                                                                                       Neural-crest-derived Neuroendocrine Progenitor Cell N. Mori, S.J. Birren, R. Stein,                                                                                                                                                D. Stemple, D.J. Vandenbergh, C.W Wuenschell, and D.J. Anderson    255 	 Studies of Cortical Development Using Retrovirus Vectors C.L. Cepko, C.P. Austin, C. Walsh, E.F. Ryder, A. Halliday, and S. Fields-Berry     265 	  Guidance of Developing Axons by Diffusible Chemoattractants M. Placzek, M. Tessier-Lavigne, T. Yamada, J. Dodd, and T.M. Jessell    279 	Mechanisms Regulating Cell Number and Type in the Mammalian Central Nervous System R. McKay, N. Valtz, M. Cunningham, and T. Hayes    291 Place-dependent Cell Adhesion, Process Retraction, and Spatial Signaling in Neural Morphogenesis G.M. Edelman and B.A. Cunningham    303 | Cadherin Subclasses: Differential Expression and Their Roles in Neural Morphogenesis 			M. Takeich4 H. Inuzuka, K. Shimamura, T. Fujimori, and A. Nagafuchi    319 	    Molecular Genetics of Neuronal Recognition in Drosophila: Evolution and Function of                                                                                                                     Immunoglobulin Superfamily Cell Adhesion Molecules G. Grenningloh, A.J. Bieber,                                                                                                                                               E.J. Rehm, P.M. Snow, Z.R. Traquina, M. Hortsch, N.H. Patel, and C.S. Goodman     327 	  Neuronal Receptors That Regulate Axon Growth L.F. Reichardt, B. Bossy, S.                                                                                                                               Carbonetto, I. de Curtis, C. Emmett, D.E. Hall, M.J. Ignatius, F. Lefcort, E.                                                                                                                                              Napolitano, T. Large, K.M. Neugebauer, and K.J. Tomaselli    341 	   Directional Cues for Retinal Axons B. Stahl, Y. von Boxberg, B. Mililer, J. Walter, U. Schwarz, and F. Bonhoeffer    351  Neuronal Growth Cone as an Integrator of Complex Environmental Information S.B. Kater and P.B. Guthrie    359 	 Neurotrophic Factors, Their Receptors, and the Signal Transduction Pathways They                                                                                                                              Activate G.D. Yancopoulos, P.C. Maisonpierre, N.Y. Ip, T.H. Aldrich, L. Belluscio,                                                                                                                                                      T.G. Boulton, M.H. Cobb, S.P. Squinto, and M.E. Furth     371 	 Compartmentalization of Acetylcholine Receptor Gene Expression during Develop-                                                                                                                                       ment of the Neuromuscular Junction J.P. Changeux, C. Babinet, J.L. Bessereau, A.                                                                                                                                          Bessis, A. Cartaud, J. Cartaud, P. Daubas, A. Devillers- Thiery, A. Duclert, J.A.                                                                                                                                                  Hill, B. Jasmin, A. Klarsfeld, R. Laufer, H.O. Nghiem, J. Piette, M. Roa, and A.M.                                                                                                                                 Salmon     381 Mr 42,000 ARIA: A Protein That May Regulate the Accumulation of Acetylcholine                                                                                                                             Receptors at Developing Chick Neuromuscular Junctions D.L. Falls, D.A. Harris,                                                                                                                                         F.A. Johnson, M.M. Morgan, G. Corfas, and G.D. Fischbach    397    The Agrin Hypothesis U.J. McMahan    407    S-Laminin J.R. Sanes, D.D. Hunter, T.L. Green, and J.P. Merlie    419   NMDA Receptor as a Mediator of Activity-dependent Synaptogenesis in the Develop- ing Brain M. Constantine-Paton    431 	  Construction of Modular Circuits in the Mammalian Brain D. Purves and A.-S. LaMantia    445 	  Target Selection by Cortical Axons: Alternative Mechanisms to Establish Axonal                                                                                                                             Connections in the Developing Brain D.D.M. O'Leary, A.R. Bicknese, J.A. De                                                                                                                                        Carlos, C.D. Heffner, S.E. Koester, L.J. Kutka, and T. Terashima    453    Pioneer Neurons and Target Selection in Cerebral Cortical Development C.J. Shatz, A. Ghosh, S.K. McConnell, K.L. Allendoerfer, E. Friauf, and A. Antonini    469 	  Activity-dependent Regulation of Gene Expression in Adult Monkey Visual Cortex E.J. Jones, D.L. Benson, S.H.C. Hendry, and P.J. Isackson    481   Factors Involved in the Establishment of Specific Interconnections between Thalamus and Cerebral Cortex C. Blakemore and Z. Molnar    491  Expression of Neural Proteoglycans Correlates with the Acquisition of Mature Neuro-                                                                                                                                       nal Properties in the Mammalian Brain S. Hockfield, R.G. Kalb, S. Zaremba, and H.                                                                                                                               Fryer    505	 Experimental and Theoretical Studies of the Organization of Afferents to Single                                                                                                                                Orientation Columns in Visual Cortex M.P. Stryker, B. Chapman, K.D. Miller, and K.R. Zahs    515   Sensory and Motor Systems 	    Chemosensory Cell Function in the Behavior and Development of Caenorhabditis elegans C.I. Bargmann, J.H. Thomas, and H.R. Horvitz    529    Bacterial Microprocessing H.C. Berg    539 	 Ultrastructural Correlates of Mechanoelectrical Transduction in Hair Cells of the Bullfrog's Internal Ear R A. Jacobs and A.J. Hudspeth    547    Model of phototransduction in Retinal Rods V. Torre, S. Forti, A. Menini, and M. Campani    563 			  Similar Algorithms in Different Sensory Systems and Animals M. Konishi    575 	   Specialized Subsystems for Processing Biologically Important Complex Sounds: Cross-                                                                                                                             correlation Analysis for Ranging in the Bat's Brain N. Suga, J.F. Olsen, and J.A.                                                                                                                                 Butman    585 		   Associative Memory Function in piriform (Olfactory) Cortex: Computational Modeling                                                                                                                               and Neuropharmacology M.E. Hasselmo, M.A. Wilson, B.P. Anderson, and J.M.                                                                                                                                   Bower    599 	 Neural Image Transformation in the Somatosensory System of the Monkey: Com-                                                                                                                                                parison of Neurophysiological Observations with Responses in a Neural Network                                                                                                                                                Model I.N. Bankman, S.S. Hsiao, and K.O. Johnson    611 Protein-Chromophore Interactions in Rhodopsin Studied by Site-directed Mutagenesis J. Nathans    621 	  Cone Excitations and Color Vision T.W. Kraft, C.L. Makino, R.A. Mathies, J.                                                                                                                                                              Lugtenburg, J.L. Schnapf, and D.A. Baylor    635 	 |